Organ ATTACK! blends medically accurate terminology with immature potty humor, creating a semi-educational and humorous experience.

In the game, each player is dealt a set of organs. The players use immunity, affliction, and other tactical cards to protect themselves while inflicting disease & bodily harm on their opponents. For example:

- Give Gallbladder gallstones

- Afflict Thyroid with thyroiditis

- Subject Bowels to the wrath of a day-old burrito from a back-alley food cart

The last person with at least one organ remaining wins.

Note: May not be suitable for players who are sensitive about discussing medical conditions (for example, playing a "Cancer" card on an opponent).