The Walking Dead Card Game, based on Wolfgang Kramer's 6 nimmt!, features the same basic gameplay as that card game while adding ten character cards and two modes of play: Survival and Hero.

To play the game, you shuffle the 104 number cards, lay out four cards face-up to start the four rows, then deal a number of cards to each player. Each turn, players simultaneously choose and reveal a card from their hand, then add the cards to the rows, with cards being placed in ascending order based on their number; each card is placed in the row that ends with the highest number that's below the card's number. When the sixth card is placed in a row, the owner of that card claims the other five cards and the sixth card becomes the first card in a new row.

In addition to a number from 1 to 104, each card has a zombie point value. In Survival mode (for 3-10 players), players want to collect as few points as possible, while in Hero mode (for 2-6 players) you want to collect more zombie points than anyone else. In Hero mode, each player has a single-use character card that can give you an extra advantage in the round in which you play it.